Hanada felt most connected to Touko, as he related to her feelings of self-hatred, while Kato identified with Yuu. Kato believed bringing his perspective as an outsider made the anime more interesting, as he imagined that someone more familiar with the genre would produce something with a more limited appeal. Touko's decision to make Yuu her campaign manager doesn't settle well with her long-time friend Sayaka Saeki, but Sayaka decides to help Yuu nonetheless.

Bauman agreed with Henderson, additionally praising Sayaka's story in the light novel spinoff series, and describing Riko and Miyako as "queer adult figures guiding the next generation". While Nakatani was confident in Kato's skill as a director, she was nervous about letting others handle her story, as she was not certain if she would be involved. Touko expresses that she feels emotionally reliant on Yuu, as she is the only one to whom Touko can be vulnerable. During school break, Yuu meets up with some of her friends from middle school, one of which was turned down by her crush.

Concerned, Yuu has Koyomi change the ending to have the protagonist choose to be herself instead of conforming to a specific person's view, believing that this will help Touko come to terms with herself. in a piece for Crunchyroll, said that the story avoided depicting Yuu as "broken" and showed her as an asexual individual who was nonetheless capable of a fulfilling relationship with Touko.

She asks the visitors for important dates but none of them work as the password - however, when she adds them together, the sum turns out to be the password. She developed many ideas for different plots and characters, almost all of which were ultimately scrapped, except for Touko's character design. This aspect of his character also served to preclude him as a potential romantic interest for Yuu or Touko. In a piece for Anime Feminist, Alex Henderson also praised Sayaka's character arc, the depiction of Riko and Miyako's relationship, and their role in her story, as upending the "just a phase" framing of Class S tropes. Hanada felt that this contributed to the success of their collaboration, as they did not clash with one another over how to portray either character.And the reason she let Touko kisses her all the time, was it, again, because she was in denial or ignorant of her own feelings toward Touko. There were several additions in the anime that Nakatani enjoyed, such as Yuu's student council election speech. No wa mentir, la obra es muy obvia, sirve para que Nanami se dé cuenta de qué sigue una vez que baje del escenario. However, we also see them have to almost reset and look at what they have been doing with their lives. As Touko's role as the student council president was decided, Nakatani conceived Sayaka, Touko's friend in the student council, who would have an unrequited crush on Touko.

Bloom into You is a charming love story about two young women who together discover that their dreams of a heart-pounding romance can indeed come true. And lastly, something I never understood: Why did Yuu run away without letting Touko explains herself as soon as she said ''I'm sorry''? As Beautiful Bones' source material was a novel series, Kato had not had to adhere to pre-existing visuals, and he described working on a manga adaptation as a challenge for this reason. Kato assured Nakatani that he cared about the original manga and wanted to create a faithful adaptation, assuaging her concerns. Because her works were primarily about relationships between girls (a fact which Nakatani attributed to the Touhou series' almost entirely female cast), she gained a reputation as an author of yuri manga.Friedman later praised a scene in the fifth volume for seeing Yuu become "an active participant in the narrative" in a scene wherein Yuu urges Touko to not depend on her for fulfillment. The upbeat tone of the ending theme "hectopascal" was chosen to "reset [the viewers'] feelings", thus leaving them happy and eager to see the next episode rather than anxious about the plot's development, and the more heavy and emotional tone of the opening was chosen to contrast this choice. Yuu reflects on how similar the relationship between her and Touko is to the patient and her lover’s, but she knows she also doesn’t want to be the only person Touko can be herself around. Yuu finally confesses her feelings to Touko and the reader is led to think that from then everything would be wonderful, but Touko can't act and answer affirmatively about it. The anime features several instances of Yuu depicted underwater as a visual metaphor, including one specific sequence from the beginning of the first episode where she reaches out through the water.