Papaleo E, Unfer V et al. Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction. Gynecol Endocrinol. 2007 Dec;23(12):700-3. Epub 2007 Oct 10. Mashayekh-Amiri S, Mohammad-Alizadeh-Charandabi S, Abdolalipour S, Mirghafourvand M Myo-inositol supplementation for prevention of gestational diabetes mellitus in overweight and obese pregnant women: a systematic review and meta-analysis. Diabetol Metab Syndr. (2022-Jul-06) Needless to say, polycystic ovary syndrome is complex, commonly difficult to diagnose and is often missed completely. 4,5 Levine J. Controlled trials of inositol in psychiatry. Eur Neurops

What’s more, inositol may improve insulin’s action in women with polycystic ovary syndrome (PCOS), though the results are mixed ( 12, 13, 14). Weight - Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, Vieste GD, Benedetto AD, D'Anna R One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome Climacteric. (2012 Oct) Clements RS, Darnell B Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr. (1980-Sep) J., et al., Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome. Life Sciences, 2019. 236. J.C. and A. Dunaif, Should all women with PCOS be treated for insulin resistance? Fertil Steril, 2012. 97(1): p. 18-22.Glycemic Control - Corrado F, D'Anna R, Di Vieste G, Giordano D, Pintaudi B, Santamaria A, Di Benedetto A The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes Diabet Med. (2011 Aug) Nerve pain in people with diabetes ( diabetic neuropathy). Taking inositol by mouth doesn't seem to improve the symptoms of nerve pain caused by diabetes. There are two main forms of inositol used in supplements, namely myo-inositol (MYO) and D-chiro-inositol (DCI). A 2017 randomised controlled trial was carried out to compare the effects of metformin and myo-inositol on clinical, metabolic and genetic parameters in women with PCOS. The researchers concluded that, “overall, taking myo-inositol, compared with metformin, for 12 weeks in patients with PCOS with hyperinsulinism and normoinsulinism had beneficial effects on total testosterone, mFG scores, serum hs-CRP levels and gene expression of IL-1, but did not affect other hormonal profiles, NO levels or gene expression of IL-8 and TNF-α.” 26

Hallman M, et al. Inositol supplementation in premature infants with respiratory distress syndrome. N Engl J Med 1992;326:1233-9. View abstract. Arentz S, Smith CA, Abbott J, Bensoussan A. Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis. BMC Complement Altern Med. 2017;17(1):500. View abstract. Alexandra Howlett, Arne Ohlsson, Nishad Plakkal Inositol in preterm infants at risk for or having respiratory distress syndrome Cochrane Database Syst Rev. (2019 Jul 8)Insulin resistance, a problem with your body’s ability to respond to insulin, is considered one of the key factors associated with conditions like metabolic syndrome ( 8). J.E., et al., Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N Engl J Med, 1999. 340(17): p. 1314-20. Metformin has limited use cases for PCOS. For example, the quality of evidence supporting its benefits for fertility is “low” [ 44]. The Endocrine Society Clinical Practice Guidelines state that it “has limited or no benefit in treating hirsutism, acne, or infertility [ 45].” Facchinetti F, Appetecchia M, Aragona C, et al. Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond. Expert Opin Drug Metab Toxicol. 2020;16(3):255-74. doi:10.1080/17425255.2020.1737675

Glycemic Control - Genazzani AD, Lanzoni C, Ricchieri F, Jasonni VM Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome Gynecol Endocrinol. (2008 Mar)Du Y, He Y, Wang YL, Zhou JG, Chen C The efficacy and safety of inositol supplementation in preterm infants to prevent retinopathy of prematurity: a systematic review and meta-analysis. BMC Ophthalmol. (2019-Jun-25) M.G., et al., Inositol for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev, 2018. 12(12): p. Cd012378. Myo-inositol is one supplement in particular which has received widespread attention for the potential role it has to play in supporting women with PCOS. And much research to date indicates that this novel supplement has the potential to provide support for many of these key areas. Fertility - Lisi F, Carfagna P, Oliva MM, Rago R, Lisi R, Poverini R, Manna C, Vaquero E, Caserta D, Raparelli V, Marci R, Moscarini M Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study Reprod Biol Endocrinol. (2012 Jul 23)

Depression Symptoms - Joseph Levine, Mirtha Gonsalves, Izak Babur, Shaul Stier, Avner Elizur, Ora Kofman, R. H. Belmaker Inositol 6 g daily may be effective in depression but not in schizophrenia Human Psychopharmacology: Clinical and Experimental. () Berridge MJ The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease. Physiol Rev. (2016-Oct)Unfer V, Carlomagno G, et al. Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials. Gynecol. Endocrinol. 2012. 28 509–515. Miñambres I, Cuixart G, Gonçalves A, Corcoy R Effects of inositol on glucose homeostasis: Systematic review and meta-analysis of randomized controlled trials Clin Nutr. (2019 Jun) Over time, inositol therapy results in better hormone balance for all types of PCOS [ 5, 6, 14]. 3. Myo-Inositol Can Enhance Fertility