W. Travis Hanes III; Frank Sanello (February 1, 2004). The Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks. pp.88–. ISBN 978-1-4022-5205-1. Giving up opium after using it for a long time is challenging because the body must get used to functioning without it. Withdrawing from opium is similar to withdrawing from other opioid drugs. Office of the Commissioner. "Legislation – Controlled Substances Act". Fda.gov . Retrieved January 25, 2017. PAPADAKI, P. G. KRITIKOS, S. P. "The history of the poppy and of opium and their expansion in antiquity in the eastern Mediterranean area". Unodc.org. UNODC- Bulletin on Narcotics – 1967 Issue 4 – 002 . Retrieved May 31, 2022. {{ cite web}}: CS1 maint: multiple names: authors list ( link)

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Forbes, Andrew; Henley, David (2011). Traders of the Golden Triangle. Chiang Mai: Cognoscenti Books. ASIN B006GMID5K Anderson, Stuart; Berridge, Virginia (2000). "Opium In 20th-Century Britain: Pharmacists, Regulation And The People". Addiction. 95 (1): 23–36. doi: 10.1046/j.1360-0443.2000.951234.x. PMID 10723823. Pseudo-Apuleius: Papaver". Archived from the original on September 28, 2007 . Retrieved June 15, 2007.

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Chen Yung-Fa (1995). "The Blooming Poppy under the Red Sun: The Yan'an Way and the Opium Trade". In Tony Saich; Hans J. Van de Ven (eds.). New Perspectives on the Chinese Communist Revolution. M.E. Sharpe. pp.263–298. ISBN 978-1-56324-428-5. Liang, Bin; Lu, Hong (2013). "Discourses of drug problems and drug control in China: Reports in the People's Daily, 1946–2009". China Information. 27 (3): 302. doi: 10.1177/0920203X13491387. S2CID 147627658. Smoking of opium came on the heels of tobacco smoking and may have been encouraged by a brief ban on the smoking of tobacco by the Ming emperor. The prohibition ended in 1644 with the coming of the Qing dynasty, which encouraged smokers to mix in increasing amounts of opium. [1] In 1705, Wang Shizhen wrote, "nowadays, from nobility and gentlemen down to slaves and women, all are addicted to tobacco." Tobacco in that time was frequently mixed with other herbs (this continues with clove cigarettes to the modern day), and opium was one component in the mixture. Tobacco mixed with opium was called madak (or madat) and became popular throughout China and its seafaring trade partners (such as Taiwan, Java, and the Philippines) in the 17th century. [47] In 1712, Engelbert Kaempfer described addiction to madak: "No commodity throughout the Indies is retailed with greater profit by the Batavians than opium, which [its] users cannot do without, nor can they come by it except it be brought by the ships of the Batavians from Bengal and Coromandel." [20] Despite drastic penalties and continued prohibition of opium until 1860, opium smuggling rose steadily from 200 chests per year under the Yongzheng Emperor to 1,000 under the Qianlong Emperor, 4,000 under the Jiaqing Emperor, and 30,000 under the Daoguang Emperor. [61] The illegal sale of opium became one of the world's most valuable single commodity trades and has been called "the most long continued and systematic international crime of modern times". [62] Opium smuggling provided 15 to 20 percent of the British Empire's revenue and simultaneously caused scarcity of silver in China. [63] Musto, David F. The American Disease: Origins of Narcotic Control. New York: Oxford University Press, 1987.

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Ahmad, Diana L. The Opium Debate and Chinese Exclusion Laws in the Nineteenth-century American West (University of Nevada Press, 2007). Drugs and Racism in the Old West. a b Commissioner Jesse B. Cook (June 1931). "San Francisco's Old Chinatown". San Francisco Police and Peace Officers' Journal . Retrieved September 22, 2007. The use of diethyl ether and chloroform for general anesthesia began in 1846–1847, and rapidly displaced the use of opiates and tropane alkaloids from Solanaceae due to their relative safety. [103] a b c d e Brown Richard Harvey (2002). "The Opium Trade And Opium Policies In India, China, Britain, And The United States: Historical Comparisons And Theoretical Interpretations". Asian Journal of Social Science. 30 (3): 623. doi: 10.1163/156853102320945420. Recreational use of opium was part of a civilized and mannered ritual, akin to an East Asian tea ceremony, prior to the extensive prohibitions that came later. [44] In places of gathering, often tea shops, or a person's home servings of opium were offered as a form of greeting and politeness. Often served with tea (in China) and with specific and fine utensils and beautifully carved wooden pipes. The wealthier the smoker, the finer and more expensive material used in ceremony. [44] The image of seedy underground, destitute smokers were often generated by anti-opium narratives and became a more accurate image of opium use following the effects of large scale opium prohibition in the 1880s. [44] Prohibitions in China [ edit ]

In Eastern culture, opium is more commonly used in the form of paregoric to treat diarrhea. This is a weaker solution than laudanum, an alcoholic tincture which was prevalently used as a pain medication and sleeping aid. Tincture of opium has been prescribed for, among other things, severe diarrhea. [148] Taken thirty minutes prior to meals, it significantly slows intestinal motility, giving the intestines greater time to absorb fluid in the stool. As the power of the Roman Empire declined, the lands to the south and east of the Mediterranean Sea became incorporated into the Islamic Empires. Some Muslims believe hadiths, such as in Sahih Bukhari, prohibits every intoxicating substance, though the use of intoxicants in medicine has been widely permitted by scholars. [16] Dioscorides' five-volume De Materia Medica, the precursor of pharmacopoeias, remained in use (which was edited and improved in the Arabic versions [17]) from the 1st to 16th centuries, and described opium and the wide range of its uses prevalent in the ancient world. [18] Opium poppies are popular and attractive garden plants, whose flowers vary greatly in color, size and form. A modest amount of domestic cultivation in private gardens is not usually subject to legal controls. In part, this tolerance reflects variation in addictive potency. A cultivar for opium production, Papaver somniferum L. elite, contains 91.2 percent morphine, codeine, and thebaine in its latex alkaloids, whereas in the latex of the condiment cultivar "Marianne", these three alkaloids total only 14.0 percent. The remaining alkaloids in the latter cultivar are primarily narcotoline and noscapine. [114] Robinson SL, Rowbotham DJ, Smith G (July 1991). "Morphine compared with diamorphine. A comparison of dose requirements and side-effects after hip surgery". Anaesthesia. 46 (7): 538–40. doi: 10.1111/j.1365-2044.1991.tb09650.x. PMID 1862890. S2CID 35289009.

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The standard medical use of opium persisted well into the 19th century. US president William Henry Harrison was treated with opium in 1841, and in the American Civil War, the Union Army used 175,000lb (80,000kg) of opium tincture and powder and about 500,000 opium pills. [1] During this time of popularity, users called opium "God's Own Medicine". [36] The Persian physician Abū ‘Alī al-Husayn ibn Sina ("Avicenna") described opium as the most powerful of the stupefacients, in comparison to mandrake and other highly effective herbs, in The Canon of Medicine. The text lists medicinal effects of opium, such as analgesia, hypnosis, antitussive effects, gastrointestinal effects, cognitive effects, respiratory depression, neuromuscular disturbances, and sexual dysfunction. It also refers to opium's potential as a poison. Avicenna describes several methods of delivery and recommendations for doses of the drug. [24] This classic text was translated into Latin in 1175 and later into many other languages and remained authoritative until the 19th century. [25] Şerafeddin Sabuncuoğlu used opium in the 14th-century Ottoman Empire to treat migraine headaches, sciatica, and other painful ailments. [26] Reintroduction to Western medicine [ edit ] Latin translation of Avicenna's Canon of Medicine, 1483 always carry naloxone for emergencies, and encourage family and friends to learn how to use take home naloxone – a medicine that can reverse the effects of an opioid overdose (more information on naloxone is provided below) · avoid mixing drugs (polydrug use) – mixing opioids with depressant drugs such as alcohol or benzodiazepines can greatly increase the risk of overdose Alfred W. McCoy (1972). "The politics of heroin in Southeast Asia". Archived from the original on October 7, 2007 . Retrieved September 24, 2007.The Greek gods Hypnos (Sleep), Nyx (Night), and Thanatos (Death) were depicted wreathed in poppies or holding them. Poppies also frequently adorned statues of Apollo, Asclepius, Pluto, Demeter, Aphrodite, Kybele and Isis, symbolizing nocturnal oblivion. [1] Islamic societies (500–1500 CE) [ edit ] Opium users in Java during the Dutch colonial period, c. 1870 Ms Louise Foxcroft (June 28, 2013). The Making of Addiction: The 'Use and Abuse' of Opium in Nineteenth-Century Britain. Ashgate Publishing, Ltd. pp.66–. ISBN 978-1-4094-7984-0.

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The production methods have not significantly changed since ancient times. Through selective breeding of the Papaver somniferum plant, the content of the phenanthrene alkaloids morphine, codeine, and to a lesser extent thebaine has been greatly increased. In modern times, much of the thebaine, which often serves as the raw material for the synthesis for oxycodone, hydrocodone, hydromorphone, and other semisynthetic opiates, originates from extracting Papaver orientale or Papaver bracteatum. Anil Aggrawal (1995). "CHAPTER 2: THE STORY OF OPIUM". Narcotic Drugs. New Delhi: National Book Trust. ISBN 978-81-237-1383-0.Association for Asian Studies. Southeast Conference (1979). Annals, Volumes 1–5. The Conference. p.51 . Retrieved April 29, 2011.