Gjoneska, E. et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature 518, 365–369 (2015). You may also come across oil waterproofing products. Just like the previous options, these types of products are specifically formulated for waterproofing. But, they come in oil consistency. Different brands have varying application methods. However, most follow the same principle. In fact, this standard method doesn’t only apply to wax treatments. It can also be used for applying other types of waterproofing products. To reproof your leather boots, follow the steps below;

Here at Grangers, we’re big animal lovers so we have never tested on animals and all of our products have and always will be cruelty-free. That’s why we’ve pulled together this list of key factors for Grangers G-Wax below, to help you choose if it’s the right product for you and your budget. Pearson, K. Mathematical contributions to the theory of evolution. XI. On the influence of natural selection on the variability and correlation of organs. Philos. Trans. R. Soc. Math. Phys. Eng. Sci. 200, 1–66 (1903). Morris, A. P. et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981–990 (2012). There are however some methods that you can use to determine a product’s quality without needing to physically have it.If you want to opt for a natural waterproofing product, wax is the way to go. You can find a variety of different waterproofing wax in the market. To use wax, you must first warm it to soften it. You can even use a blow dryer to soften it.

Marioni, R. E. et al. GWAS on family history of Alzheimer’s disease. Transl. Psychiatry 8, 99 (2018). Grant, S.F.A. et al. Variant of transcription factor 7–like 2 ( TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 38, 320–323 (2006). The material the product is made from is often a sign of the quality for Cleaning & Proofing. Take a look at the product details over at Go Outdoors to get a feel for this.

Finucane, H. K. et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet. 47, 1228–1235 (2015). Other waterproofing products come in spray form. Typically, spray waterproofing products are either water-based or silicone-based. Unlike wax treatment, silicone spray treatment is time-saving. Also, Nikwax now seem to only sell the rubbish cream (comes in a tube rather than a tin and is very thin). We measure performance using the ISO 14001 Environmental standard and we also work to the ISO 9001 standard for quality control. Hayes, B. J., Bowman, P. J., Chamberlain, A. J. & Goddard, M. E. Genomic selection in dairy cattle: progress and challenges. J. Dairy Sci. 92, 433–443 (2008).

Joshi, P.K. et al. Variants near CHRNA3/ 5 and APOE have age- and sex-related effects on human lifespan. Nat. Commun. 7, 11174 (2016). We support the Responsible Down Standard (RDS) by making sure that we only work with those brands that use ethically sourced down.

Howie, B.N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009). Clothing Repel and Performance Repel Plus both offer effective, durable protection, replenishing your garment's DWR. Their difference, however, lies in their method of application. Clothing Repel is a simple, wash-in solution that is ideal for achieving complete protection. Performance Repel Plus is an easy-to-use, spray-on product that is excellent for targeting areas prone to abrasion (cuffs, collars, shoulders, etc.) and offering those places extra protection. Hunter, D.J. et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat. Genet. 39, 870–874 (2007).