Neonates, pregnant and breast-feeding women and older adults (> 60 years) should not receive more than one dose (see section 4.6). Neonates and older people (> 60 years) are at higher risk of adverse health effects if they receive repeated doses of stable iodine (see sections 4.4 and 4.6). Iodine prophylaxis protects against inhaled or ingested radioiodine and has no effect on other ingested radionuclides.

Also you can help to make sure that medicines remain as safe as possible by reporting anyunwanted side effects via the internet at www.mhra.gov.uk/yellowcard. Alternatively you cancall Freephone 0808 100 3352 (available from10 a.m. to 2 p.m. Mondays to Fridays) or fill in apaper form available from your local pharmacy. 5. How to store ThySat Only take potassium iodide if state or local health authorities suggest you do so. During an emergency, health officials will send out an announcement. Your health department will then tell you when it’s OK to take potassium iodide. They’ll also tell you when you can stop the medication.

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But the salt doesn’t protect the rest of your body from radioactive iodine, only your thyroid. It also can’t reverse any health issues caused by radioactive iodine if your thyroid was already damaged. In overdose, symptoms of iodism such as headache, pain and swelling of the salivary glands, fever or laryngitis, swelling or inflammation of the throat, gastrointestinal upset and diarrhoea can occur. Pulmonary oedema can also occur. The Food and Drug Administration (FDA) released guidance in December 2001 on how to safely use potassium iodide. In pill or liquid form, it can help protect you during a nuclear radiation emergency. How Does Potassium Iodide Work? In cases of exposure to radioiodine from nuclear accidents, dosing of potassium iodide should be based on emergency plans and predetermined operational intervention levels. Risk benefit of administration of stable radioiodine should be considered for the different age groups at risk. Pregnant and lactating women, neonates, infants and children should be treated first. A single dose of potassium iodide gives adequate protection for one day. Prolonged exposure may require repeat dosing, however repeat dosing in the neonate, and in pregnant and lactating women should be avoided (see section 4.2). Iodine prophylaxis is used against inhaled radioiodine and should not be the main prophylaxis for ingested contamination. an overactive thyroid gland (characterised byweight loss, increased appetite, intolerance toheat and increased sweating)

The groups most likely to benefit from treatment with iodine tablets after exposure to radioactive iodine are children, adolescents, and pregnant and breast-feeding women as well as people living in iodine deficient areas (who are more likely to be affected by exposure to radioactive iodine). If the supply of stable iodine is limited, priority should be given to children and younger adults.

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Hyperthyroidism, iodine induced autoimmunity (Grave's and Hashimoto type), toxic nodular goitre and iodine-induced hypothyroidism have been reported as side effects of iodine therapy. An overactive thyroid gland, thyroiditis, and an enlarged thyroid gland with or without development or myxoedema have also been reported. The risk of iodine induced hyperthyroidism may be increased in patients with asymptomatic nodular goitre or latent Graves' disease, who are not under medical care. Prophylactic administration of iodide to the pregnant mother should also be effective for the foetus. A newborn (a baby less than 1 month old) could develop hypothyroidism if they take more than the suggested amount of potassium iodide. Hypothyroidism is a condition where your thyroid hormone levels are too low. If doctors don’t treat this, it can cause brain damage. To keep your infant safe:

In case of prolonged exposure, repeat dosing may be necessary although if you are pregnantor breastfeeding you should normally not takemore than two doses. You must also get medicaladvice since ThySat may affect the thyroidof your child and tests from your doctor canestablish and correct this. Babies up to a monthold should only receive one dose and shouldhave their thyroid function assessed by theirdoctor. Newborns are particularly sensitive to iodine overload, probably by an immature regulation system. For neonates who have been administered potassium iodide in the first few weeks of life TSH levels and, if necessary, T4 levels should be monitored and appropriate replacement therapy given (see also section 4.4). The tablets are white to yellowish slightly marbled round tablets with a smooth surfacewithout any defects, cross-scored for ease ofbreaking. In children of 3 to 12 years 50% of the adult dose should be given and in children of 1 month to 3 years the dose should be 25% of the adult dose. Owing to the sensitivity of the neonate and foetus thyroid to large doses of iodine, repeated administration of stable iodine should be avoided for neonates and pregnant and lactating women. Neonates will not require further doses. Pregnant and breastfeeding women should take a maximum of two doses.For children the medicine may be crushed and mixed with milk, water or juice before administration. Because of this, it’s important to give children, especially newborns, potassium iodide during an emergency.

Iodine prophylaxis should be undertaken in case of a nuclear accident or when radioactive iodineis released, in all people involved includingpregnant and breastfeeding women locatedin endangered area. If you are pregnant orbreastfeeding, this medicine can be taken overa short period of time. You should continue tobreast feed if you are taking this medicine. Physiological serum concentrations in humans vary from 1 to 5 |LLg/l (40 to 80 nmol/l) at daily iodine intakes of 150 to 250 

Summary of medicine characteristics - POTASSIUM IODIDE 65 MG TABLETS

You should take a different amount of potassium iodide based on your age and weight. There’s a liquid form, a 65-milligram pill, and a 130-milligram pill. For kids and babies that can’t take pills, you can crush or cut pills to create smaller doses. Or you can give them a liquid form of potassium iodide.