Kim, Y., Alpmann, P., Blaum-Feder, S., Kraemer, S., Endo, T., Lu, D., & Schmidt-Wolf, I. G. (2011). ‘Increased in vivo efficacy of lenalidomide by addition of piroctone olamine.’ In vivo, 25(1), 99-103. Nizoral is probably the most effective shampoo on the market to control dandruff caused by seb derm.

Note: There’s no straightforward way to tell if a shampoo is utilizing the ingredient as a preservative or active ingredient – as the exact concentration isn’t required by regulators – and so you should always read the product description.] What Are the Possible Side Effects of Piroctone Olamine?

Where did it come from?

Alpecin Dandruff Killer Shampoo is formulated with piroctone olamine to kill the bacteria that causes dandruff. And on top of this Sebclair uses an ultra-mild, natural preservative system, no essential oils, no fragrance, no parfum and no allergens. Seb Derm is thought it be associated with a Malassezia yeast on the scalp, with anti-fungal shampoos used to reduce this growth. Very few high-quality clinical trials have been performed on the efficacy of piroctone olamine-based shampoos. In 2010, researchers at the cosmetic company Beiersdorf published data suggesting a piroctone olamine/climbazole combination shampoo was equally as effective at reducing dandruff compared to zinc pyrithione in 50 participants – although more research is required [5]. Exiting the 30ml tube as a white, rich cream with a very gentle fragrance you can’t quite put a finger on the Sebclair Non-Steroidal Cream is smooth and easy to massage in.

Sebclair® Shampoo is indicated in the treatment of the diseases of the scalp (Seborrheic dermatitis, Pityriasis versicolor) and as anti-dandruff treatment. The recognized ingredient Sebclair use is Piroctone Olamine an anti-fungal active with gentler properties than classical Ketoconazole or Selenium Sulfide. Studies show when Piroctone Olamine at 0.75% is combined with Salicylic Acid at 2%, the anti-dandruff effects are even greater than traditional shop bought dandruff formulas containing Zinc Pyrithione. Perhaps more noteworthy, in 2001, it was found that Seborrheic Dermatitis sufferers have an altered skin structure that is improved significantly with zinc pyrithione treatment[7]. An outstanding shampoo, formulated with precision and care, and the best dandruff shampoo we've seen this year. Runners UpWithout understanding your condition, it’s pointless to even try to find the right shampoo. You have to match the active ingredient to the type of dandruff. Dr. Matthew Zirwas recommended trying a shampoo for, “at least a month because if your old shampoo had ingredients that were causing a dandruff-like rash of their own, it will take 4-8 weeks for that ingredient to work its way out of your body after you start the new stuff.”

Dermatologists from the American Academy of Dermatology mirror this advice. It’s fairly easy to treat and control dandruff with patience – and the right dandruff shampoo. As an added bonus, it also contains Sorbitol.Sorbitol is a humectant ie an ingredient that attracts water to itself. When such an ingredient is near your scalp, your skin can be hydrated and soothed. Great news for dry scalp sufferers. It’s also an ingredient used to break down biofilms. Biofilms accumulate at a molecular level and build up a resistance to antifungal ingredients[5]. They may just be the reason why your dandruff shampoo has stopped working. Piroctone olamine is an ingredient found in dandruff shampoos and topical skin products. Also called piroctone ethanolamine and sold under the brand name “Octopirox”, piroctone olamine is an antifungal and antimicrobial compound used to treat fungal infections of the skin, including scalp infections that cause dandruff.If there’s any we haven’t reviewed then please just drop us a line and we’ll be absolutely delighted to look into it! References