The word “folate” describes a family of nutrients found in foods, especially green leafy vegetables, beans, and eggs. These are naturally occurring and water-soluble forms of vitamin B9. (1)

The link between obesity and insufficient folate levels is very strong, but it seems that no one has figured out why. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk. methyltetrahydrofolate, or 5-MTHF, is a natural form of vitamin B9 your body is ready to absorb and use for nutritional purposes. It is now a very popular form of folate for this reason, especially among people who have problems metabolizing other forms of B9 from foods and supplements. First line treatment for colorectal cancer: In combination with the anticancer drug 5- fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy;

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis. Metformin side effects Only take it as long as recommended. The supplement needs to be taken with caution under the consultation of a health expert. Unlike other supplements, 5-MTHF should not be taken regularly unless otherwise specified. This can depend on the dosage you are taking and frequency. It is important not to replace 5-MTHF supplements with natural foods. It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Folic acid and natural folate in foods need to go through multiple chemical reactions before they become 5-MTHF, the only useful form. Generally folic acid is metabolized to Metafolin® in the enterocytes in the gut lining. At higher intakes, this mechanism is overloaded and folic acid enters the plasma unmetabolized. 2 Unmetabolized folic acid is not present in breast milk, unless maternal intakes via supplements or fortified foods are high. It is important to consider the genetic differences in ability to metabolize folic acid, which may decrease the availability of active folate.

Mod de administrare: supliment alimentar pentru adulti, 1 tableta de 1-2 ori pe zi, de preferinta in timpul mesei Raghavan R et al. Am J Clin Nutr. 2020; 112(5):1304–1317; Methylfolate is a Central Alternative to Folic Acid FEMIBION 1 sadrži kombinaciju dobro odabranih hranljivih sastojaka, uključujući najbitniji miks folata (Metafolin® i folna kiselina)*, osmišljen posebno za fazu planiranja i prvi trimestar trudnoće. Yet, this process is slow and inefficient in some people. After taking a folic acid supplement, it takes time for your body to convert all of it to 5-MTHF ( 7).

This is why all national and international health organisations advocate for folic acid supplementation before and during early pregnancy. It appears to be particular effective in those with certain genetic variations (including MTHFR) and those with elevated inflammatory markers ( 13, 14). L-Methyfolate (5-MTHF) in patients with diabetic neuropathy Hiraoka M & Kagawa Y: Genetic polymorphisms and folate status. Congenital Anomalies 2017; 57, 142-149. Folate refers to a group of water-soluble B-vitamins which play a critical role in deoxyribonucleic acid (DNA) synthesis and methylation reactions [ 1]. All folate vitamers consist of a common parent structure, but differ based on whether the pteridine ring is in an oxidized or a reduced state, the addition of one-carbon substituents at positions N5 and/or N10 and number of glutamic acid residues [ 1, 2]. Food folates are reduced and have a polyglutamate tail consisting of up to nine glutamate residues [ 1, 3]. Folic acid is a synthetic form of folate which is oxidized and contains one glutamic acid residue; this is the most stable form. Therefore, folic acid is used in food fortification and most supplements [ 1– 3]. This is a cause for concern, as high levels of unmetabolized folic acid have been associated with several health problems.