Asemi Z, Karamali M, Jamilian M, et al. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(1):222-229. doi:10.3945/ajcn.114.098616 This interaction mainly occurs within the gastrointestinal tract. When oxalates and magnesium bind tightly to each other, creating magnesium oxalate, the magnesium becomes unable to dissolve. Consequently, a significant portion of magnesium oxalate passes through the digestive system without being absorbed. Magnesium is extremely important for heart health and blood vessel health. Magnesium deficiency seems to worsen the inflammation, blood vessel constriction, blood clotting, and stress responses that trigger heart conditions. Correcting deficiency appears to improve heart health and reduces risk of death, although it is unclear whether supplementation alone is sufficient to treat these conditions.

While also helpful for the heart, magnesium orotate is believed to be the best form for metabolic improvements. Insulin, a hormone secreted by the pancreas in response to blood sugar levels, is regulated by magnesium. Magnesium plays a crucial role in controlling the release of insulin and maintaining blood sugar regulation. It is instrumental in keeping your body sensitive to insulin and preventing insulin resistance.Based on a systematic review, it was determined that magnesium supplementation for over four months led to enhanced insulin sensitivity and improved fasting glucose levels in both healthy individuals and those with health issues.

DiNicolantonio JJ, Liu J, O'Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775 Orchard TS, Larson JC, Alghothani N, et al. Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study. Am J Clin Nutr. 2014;99(4):926-933. doi:10.3945/ajcn.113.067488 Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169Contains seven forms of magnesium optimized for muscle recovery, metabolic health, improved sleep and relaxation, according to the company

Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019;26(1):e124-e132. doi:10.1097/MJT.0000000000000538 Magnesium is essential for converting the inactive thyroid hormone (T4) into its active form (T3). Without this conversion, your thyroid won’t function properly. Since T3 affects every cell and organ in your body, adequate magnesium is vital for optimal thyroid function. Interpreting serum magnesium levels can be challenging due to the influence of higher stress levels. Stress can elevate serum magnesium and magnesium excretion, even when whole-body magnesium levels are being depleted. This complexity makes it important to carefully assess magnesium status while considering the impact of stress on these readings. de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014

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Improves Sleep Quality. In a small clinical trial involving 46 elderly subjects with insomnia,[17] 500 mg of daily magnesium supplement reduced insomnia scores, sleep latency, and cortisol. Subjects also had more serum melatonin, slept deeper, and were less likely to wake up in the middle of the night.