It is important to use enough nicotine spray to control cravings, and using 1 or 2 sprays corresponds to the nicotine from a cigarette. Use one spray first and if your cravings do not disappear within a few minutes use a second spray. If 2 sprays are required to control cravings, future doses may be delivered as 2 consecutive sprays. For many smokers this means about 1-2 sprays every 30 minutes to 1 hour. Nicorette® contains nicotine. Stop smoking aid. Requires willpower. Always read the label. (12+ years) UK-NI-2300074 Nicotine craving, which is recognised as a clinically relevant symptom, is an important element in nicotine withdrawal after smoking cessation. Some symptoms may be related to nicotine withdrawal associated with stopping smoking. These can include the following: dysphoria or depressed mood; insomnia; irritability, frustration or anger; anxiety; difficulty concentrating, restlessness or impatience; decreased heart rate; and increased appetite or weight gain. These have been observed in those using the mouthspray.

In smokers with liver cirrhosis but only mild liver impairment (Child-Pugh score 5) the pharmacokinetics of nicotine is unaffected. However, in smokers with moderately impaired liver (Child-Pugh score 7) total clearance has been reported to be reduced by 40-50%. There is no information available in subjects with a Child-Pugh score > 7. Use your thumb to slide down the button until it can be pushed lightly inwards. Do not push too hard. Directions: For adults and children 12 years and over. It is important to use enough nicotine spray to control cravings. Use 1 spray first when you would normally smoke/vape, or have cravings to smoke/vape. If your cravings do not disappear within a few minutes use a second spray. If 2 sprays are required to control cravings, future doses may be delivered as 2 consecutive sprays. Do not use more than 2 sprays per dose or 4 sprays per hour or 64 sprays per day.Ideally, you should aim to stop smoking. However, it can be used in many different ways, either to completely replace all your cigarettes or if you do not feel ready to stop smoking completely, to replace certain cigarettes and therefore help you cut down the number of cigarettes you smoke. It may also help increase your motivation to quit. Diabetes mellitus: Patients with diabetes mellitus should be advised to monitor their blood sugar levels more closely than usual when quitting, and NRT is initiated as reductions in nicotine induced catecholamines released by nicotine can affect carbohydrate metabolism. Renal or hepatic impairment: This product should be used with caution in patients with moderate to severe hepatic impairment and/or severe renal impairment as the clearance of nicotine or its metabolites may be decreased with the potential for increased adverse effects. Stopping smoking: Polycyclic aromatic hydrocarbons in tobacco smoke induce the metabolism of drugs metabolised by CYP 1A2 (and possibly by CYP 1A1). When a smoker stops smoking, this may result in slower metabolism and a consequent rise in blood levels of such drugs. This is of potential clinical importance for products with a narrow therapeutic window, e.g. theophylline, clozapine and ropinirole.

The oral spray form means that the nicotine dose is administered instantaneously, and as a result the absorption of nicotine from the mouth spray is rapid: In trials, nicotine uptake from the oral nicotine spray was detected at 2 minutes, the first timepoint tested.Use of nicotine by the pregnant smoker should only be initiated after advice from a health care professional. Use one spray first and if your cravings do not disappear within a few minutes, use the second spray. Quitting smoking cold turkey is not always the most effective method, with up to 76% of unaided quitters relapsing within the first week‡, so whether you want to cut down or stop smoking completely, Nicorette® will be there through each of the stages of quitting smoking. From preparing to quit smoking to during your journey to stop smoking, there is a Nicorette® product for you.

When you stop smoking or vaping, you may notice unpleasant feelings alongside a strong desire to smoke or vape– this is known as a craving. This is because your body starts to miss the nicotine it was getting from cigarettes and vapes. All products are developed to meet Pharmaceutical standards and the highest possible quality. Quit smoking and help break the habit with Nicorette. Nicorette contains nicotine. Stop smoking aid or stop nicotine vaping aid. Requires willpower. Always read the label. Acute or chronic toxicity of nicotine in man is highly dependent on mode and route of administration. Adaptation to nicotine (e.g. in smokers/vapers) is known to significantly increase tolerability compared with non-smokers/vapers. The primary metabolite of nicotine in plasma, cotinine, has a half-life of 15 to 20 hours and concentrations that exceed nicotine by 10-fold.Danger in children: Doses of nicotine tolerated by adult and adolescent smokers or vapers can produce severe toxicity in children that may be fatal. Products containing nicotine should not be left where they may be misused, handled or ingested by children. See Section 4.9 Overdose. In males tobacco smoking reduces sperm production, increases oxidative stress, and DNA damage. Spermatozoa from smokers have reduced fertilizing capacity. Use your thumb to slide down the button until you can push it lightly inwards. Don't push too hard.

Plasma protein binding of nicotine is less than 5%. Therefore, changes in nicotine binding from use of concomitant drugs or alterations of plasma proteins by disease states would not be expected to have any significant effects on the nicotine pharmacokinetics. Clinical studies have shown that nicotine replacement products can help smokers abstain from use by relieving these withdrawal symptoms.AUC∞ estimates show the bioavailability of nicotine administered by mouth spray is somewhat higher than that of nicotine gum or lozenge. The AUC∞ of the mouth spray 2 mg measured 18.9 h*ng/mL as compared with 16.2 h*ng/mL for nicotine gum 2 mg. Allowing for differences in administered dose, bioavailability was also higher in a second study. The nicotine AUC∞ of the mouth spray 2 mg measured 14.0 h*ng/mL in comparison with 23.0 h*ng/mL and 26.7 h*ng/mL for and nicotine gum 4 mg and nicotine lozenge 4 mg, respectively. When used as directed, symptoms of overdose with nicotine may occur in patients with low pre-treatment nicotine intake or if other sources of nicotine are used concomitantly.