Kao J-C, HuangFu W-C, Tsai T-T, Ho M-R, Jhan M-K, Shen T-J, et al. The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR. Beasley DWC, editor. PLoS Negl Trop Dis. 2018;12(8):e0006715. In clinical studies Imunovir has been shown to normalise (to the patient's baseline) a deficient or dysfunctional cell-mediated immunity by evoking a Th1 type response which initiates T lymphocyte maturation and differentiation and potentiation of induced lymphoproliferative responses, in mitogen or antigen-activated cells. Similarly, the drug has been shown to modulate T lymphocyte and natural killer cell cytotoxicity, T8 suppressor and T4 helper cell functions and also to increase the number of IgG and complement surface markers. Při pandemii covidu-19 začal být lék Isoprinosine považován veřejností za jeden ze zázračných léků, přestože o jeho účinnosti neexistoval dostatek důkazů. Nesoulad v právním postavení léku stejné léčivé látky v zemích EU vedl v roce 2021 k vypsání petice na podporu změnu statutu z preskripčního léku na volně prodejný lék. [48]

Tocilizumab is given as an intravenous infusion over 1 hour at a dose of 8 mg/kg in patients who weigh more than 30 kg (maximum dose- 800 mg). This can be repeated for three additional times, 8 hours apart. Adverse reactions include upper respiratory tract infections, headache and transaminitis [ 108]. In COVID-19 clinical studies, tocilizumab was shown to be safe except for a few reports of transaminitis [ 9]. Siltuximab

Prospect Isoprinosine 1 g x 24 plicuri x 1,3 g granule pentru solutie orala

SÁNCHEZ PALACIOS, A.; QUINTERO, A.; CLAVERO GARÍN, A. Immunoregulation with methisoprinol in Sjögren's syndrome. Allergologia Et Immunopathologia. 1986-01, roč. 14, čís. 1, s. 21–29. PMID 2421565. Dostupné online [cit. 2021-04-02]. ISSN 0301-0546. PMID 2421565. Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial. medRxiv. Available from: https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v3. Fredeking TM, Zavala-Castro JE, González-Martínez P, Moguel-Rodríguez W, Sanchez EC, Foster MJ, et al. Dengue patients treated with doxycycline showed lower mortality associated to a reduction in IL-6 and TNF levels. Recent Pat Antiinfect Drug Discov. 2015;10(1):51–8. Yamamoto M, Matsuyama S, Li X, Takeda M, Kawaguchi Y, Inoue J, et al. Identification of Nafamostat as a potent inhibitor of Middle East respiratory syndrome coronavirus S protein-mediated membrane fusion using the Split-protein-based cell-cell fusion assay. Antimicrob Agents Chemother. 2016;60(11):6532–9. Isoprinosine obsahujepšeničnýškrob. Tablety sú vhodné pre osoby s celiakiou. Pacienti s alergiou na pšenicu (ktorá sa odlišuje od celiakie) nemajú užívať tento liek.

GEORGALA, Sofia; KATOULIS, Alexander C.; BEFON, Angeliki. Inosiplex for treatment of alopecia areata: a randomized placebo-controlled study. Acta Dermato-Venereologica. 2006, roč. 86, čís. 5, s. 422–424. PMID 16955187. Dostupné online [cit. 2021-04-02]. ISSN 0001-5555. DOI 10.2340/00015555-0138. PMID 16955187. DE SIMONE, C.; FAMULARO, G.; TZANTZOGLOU, S. Inosine pranobex in the treatment of HIV infection: a review. International Journal of Immunopharmacology. 1991, roč. 13 Suppl 1, s. 19–27. PMID 1726683. Dostupné online [cit. 2021-03-13]. ISSN 0192-0561. DOI 10.1016/0192-0561(91)90120-v. PMID 1726683. PMCID: PMC444295. Dostupné online [cit. 2021-03-27]. ISSN 0066-4804. DOI 10.1128/aac.2.3.224. PMID 4790561.Inglot AD. Comparison of the antiviral activity in vitro of some non-steroidal anti-inflammatory drugs. J Gen Virol. 1969;4(2):203–14. KOLB, H.; GREULICH, B.; KIESEL, U. IMMUNOTHERAPY OF TYPE I DIABETES. The Lancet. 1982-07, roč. 320, čís. 8289, s. 97–98. Dostupné online [cit. 2021-04-02]. ISSN 0140-6736. DOI 10.1016/s0140-6736(82)91715-9.