Behind the scenes, Norman Osborn manages to have the files on Ben and Peter switched, so the Jackal would think Peter is the clone and Ben is the real deal. After Jackal targets Mary Jane, Kaine leads them to Jackal's lair, only for all three to be captured. On Earth-3145, they are confronted by John Jameson at Sims Tower, known as Astro-Spider, the second spider of that reality who received his powers from a radioactive spider that bit him in spacer.

Kaine and Peter grab costumes from Peter's lab, Kaine opting for the sonic-shield " Big Time" outfit as the two head off. Peter Parker is eventually tried and convicted for Kaine's crimes because they have the same fingerprints. However, Madame Web enhanced the suit to stay permanently red, helping perpetuate the Scarlet Spider alias around Houston. In the ensuing battle, Spidercide impales him with a spike taken from nearby machinery, seriously injuring and possibly killing him.He also seems to hold some enmity towards Peter, perhaps after finding out he is the actual original Spider-Man. There are two sets of hands- one pair feature closed fists, and the second pair are open handed with his Stingers deployed. Their next attempt to hunt Kaine succeeds in brutally beating him; he barely escapes with his life, the Kravinoffs mocking that he will be "The only spider left. This is a figure to Spidey fan and New Warrior members but is an absolute most for a Spider-verse display.

The Jackal discards Kaine because the clone starts showing early signs of the degeneration process, and Kaine experiences a strong feeling of rejection similar to that between a father and son. It is revealed thanks to the Webware's reversed signal, Kaine has been cured as well, leaving him with only mild facial scars. Prior to that, it was revealed that Kaine's human body emerged from the Other's corpse similar to Peter's in the "Changes" storyline and is greeted by the Master Weaver, who soon realizes that Kaine no longer has the powers of the Other and is now dying from the carrion virus that's a side-effect of Warren's cloning process, and is not allowed to go back to his Earth to avoid anyone catching it.Kaine convinces Jessica Drew of Earth-616 to join the team, and deceives her, telling her the mission is actually a suicide mission to destroy the stone containing Solus' essence that could potentially leave them trapped to die on the radioactive Earth-3145. Kaine breaks out to try to stop Norman Osborn after finding out that he is still alive, has masterminded the Clone Saga, and killed his brother Ben.