Isabelle is the first character you encounter when you arrive in New Leaf. She acts as your secretary as the mayor of town. Isabelle is a friendly and hardworking assistant who is always eager to help make the town a better place. She has appeared in a manga called Tobidase Dōbutsu no Mori Minna de Seseragi Mura Life as one of the main characters.

In New Horizons, snooty villagers can comment on how easy to talk to and wise she is, and express desire in keeping her company, while smug villagers say that she is the real brains of the player's island. Her German name, Melinda, is related to the names Melissa (from Greek μέλισσα "honey bee", ultimately from μέλι "honey") and Linda (from Germanic lind "gentle, soft, tender"). It is also alliterative with Digby's German name, Moritz. Both siblings grew up in a cardboard box that Digby has fond memories of. The two siblings used to fight when they were puppies because Isabelle couldn't help but be mischievous and want to eat her brother's shoes. Now, they get along better, but Isabelle confesses she still feels tempted to eat her brother's shoes whenever he gets a new pair. [3] If the player sets their birthday to December 20th in New Leaf, Isabelle will comment on how she has the same birthday as the player.Isabelle was confirmed as a DLC character, along with the Villager, for Mario Kart 8, and has been available since April 23rd, 2015. Sometimes if the player talks to her while she's visiting the campground in the Welcome amiibo update, she'll reveal she's actually nearsighted, hence why she wears glasses with her casual outfit.

In New Leaf, Isabelle mentions that she still has cardboard boxes littered among her room, and is embarrassed to let Digby see. Isabelle in general may be a somewhat messy person, as Digby, who claims to be a neat freak, notes that while she is not too messy, it is enough to get on his nerves. Sometimes, if the player talks to her while visiting another town in New Leaf, she will tell the player that she has many sisters who look exactly like her. They all work as secretaries in other towns, and all of them are also named "Isabelle".

SypherPK and Fortnite Skin designer support Isabelle cosplayer against trolls

Strangely and coincidental to the naming of Isabelle and Bells, Fuffi is a German colloquial abbreviation for Fuffziger, a DM 50 coin.