Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247–257. Initiate the license verification by calling verifyLicense(). This method is exposed in the LicensingService class. It takes two parameters as input: The following architecture shows the DR activation process in case the production region becomes unavailable. Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, et al. (2004) Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 131: 839–849.

Lister R, O'Malley RC, Tonti-Filippini J, Gregory BD, Berry CC, et al. (2008) Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell 133: 523–536. Robson, T. M. et al. A perspective on ecologically relevant plant-UV research and its practical application. Photochem. Photobiol. Sci. 18, 970–988 (2019). Aravin AA, Sachidanandam R, Bourc'his D, Schaefer C, Pezic D, et al. (2008) A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell 31: 785–799. Cao, X. et al. Conserved plant genes with similarity to mammalian de novo DNA methyltransferases. Proc. Natl Acad. Sci. USA 97, 4979–4984 (2000). Pikaard, C. S. & Scheid, O. M. Epigenetic regulation in plants. Cold Spring Harb. Perspect. Biol. 6, a019315 (2014).Tip: The DRM APIs are included in the Appstore SDK. For instructions on how to add the Appstore SDK library into a new project, see Integrate the Appstore SDK Aina, R. et al. Specific hypomethylation of DNA is induced by heavy metals in white clover and industrial hemp. Physiol. Plant. 121, 472–480 (2004). Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (2003) Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A 100: 4492–4497. For crystallization, the DRM2-DNA complexes were each mixed with 1 mM SAH. Crystals for all the DRM2-DNA complexes were generated using sitting-drop vapor-diffusion method at 4°C. Each drop was prepared by mixing 0.5 μl of DRM2-DNA complex sample with 0.5 μl of precipitant solution [for DRM2-CTT, DRM2-CCG, and DRM2 C397R-CCG complexes: 2% v/v Tacsimate (pH 6.0), 0.1 M bis-tris (pH 6.5), and 20% w/v polyethylene glycol 3350; for DRM2-CAT complex: 0.1 M sodium acetate trihydrate (pH 7.0) and 12% w/v polyethylene glycol 3350; for DRM2-CCT complex: 0.1 M sodium formate (pH 7.0) and 12% w/v polyethylene glycol 3350; and for DRM2-CTG: 0.2 M potassium iodide and 20% w/v polyethylene glycol 3350 (pH 7.0)]. The crystal quality was further improved using the microseeding method. To harvest crystals, the crystals were soaked in cryoprotectants made of mother liquor supplemented with 30% glycerol before being flash-frozen in liquid nitrogen.

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Henderson IR, Jacobsen SE (2008) Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading. Genes Dev 22: 1597–1606.Johnson LM, Law JA, Khattar A, Henderson IR, Jacobsen SE (2008) SRA-domain proteins required for DRM2-mediated de novo DNA methylation. PLoS Genet 4: e1000280. Niu, X. et al. Transposable elements drive rapid phenotypic variation in Capsella rubella. Proc. Natl Acad. Sci. USA 116, 6908–6913 (2019). Kanno T, Huettel B, Mette MF, Aufsatz W, Jaligot E, et al. (2005) Atypical RNA polymerase subunits required for RNA–directed DNA methylation. Nat Genet 37: 761–765.